Injectable rabies vaccine composition and method for...

Details Injectable rabies vaccine composition and method for... Injectable rabies vaccine composition and method for...

A - Human Necessities

61

K

167/134

A61K 39/205 (2006.01)

Patent

CA 1154673

ABSTRACT An injectable rabies vaccine composition is disclosed which comprises a sterilized suspension of a minor concentration by weight of proteineous suckling mice or rat brain par- ticles of injectable particle size laden with inactivated rabies virus in an aqueous buffer solution having a slightly basic pH-value and an amount, dissolved therein, of a buffer composition sufficient to stabilize the pH at said value, said buffer composition comprising a mixture of an organic base of the formula Image wherein R1 and R2 each are hydrogen or CH2CH2OH and an acid addition salt thereof, preferably a mixture of tris (hydroxymethyl)amino methane and its hydrochloride. Also a process for preparing said vaccine composition is dis- closed. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.

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