Preparation of n-2-(6-hydroxybenzothiazolyl)-n-phenyl (or...

Details Preparation of n-2-(6-hydroxybenzothiazolyl)-n-phenyl (or... Preparation of n-2-(6-hydroxybenzothiazolyl)-n-phenyl (or...

C - Chemistry, Metallurgy

07

D

260/309.3

C07D 277/82 (2006.01)

Patent

CA 1059131

Title PREPARATION OF N-2-(6-HYDROXYBENZOTHIAZOLYL)- N'-PHENYL (OR SUBSTITUTED-PHENYL) UREAS Abstract N-2-(6-hydroxybenzothiazolyl)-N'-phenyl(or substituted-phenyl)ureas of the formula Image FORMULA I wherein R is hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy or halo are prepared by reacting 2-amino-6-hydroxy- benzothiazole with 1-2 moles of phenyl (or a sub- stituted phenyl) isocyanate and then hydrolysing any 6-phenylcarbamoyloxy compound thus produced to the corresponding 6-hydroxy derivative. These compounds are useful as immune regulants and anti-viral compounds.

232835

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