Derivatives of pyrazolo (3,4-b) thieno (2,3-d)...

Details Derivatives of pyrazolo (3,4-b) thieno (2,3-d)... Derivatives of pyrazolo (3,4-b) thieno (2,3-d)...

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 471/14 (2006.01) C07D 231/38 (2006.01) C07D 471/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 1050027

Abstract New derivatives of pyrazolo[3,4-b]thieno[2,3-d]- pyridine-2-carboxylic acids have the general formula Image wherein R and R2 each is hydrogen or lower alkyl; R1 is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl; R3 is lower alkyl, phenyl, substituted phenyl, hydroxy, lower alkoxy, Image , Image or Image , wherein the phenyl substituent is lower alkyl, halo, trifluoromethyl, amino or carboxy; R4 is hydrogen, lower alkyl or phenyl, R5 and R6 each is hydrogen or lower alkyl; R7, R8 and R9 each is hydrogen, lower alkyl or phenyl; and R10 is lower alkyl or phenyl. They are useful as antiinflammatory agents and central nervous system depressants. In addition, this type of com- pound increases the intracellular concentration of adenosine- 3', 5'-cyclic -monophosphate.

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