G - Physics – 01 – N
Patent
G - Physics
01
N
73/56
G01N 21/13 (2006.01) B01L 3/00 (2006.01) G01N 21/25 (2006.01) G01N 21/27 (2006.01) G01N 33/53 (2006.01)
Patent
CA 1122811
ABSTRACT A novel combination and a method are disclosed for detecting and measuring a predetermined substance capable of being specifically bound, for example, an antigen, an antibody, a hapten, or a low molecular weight substance, in a sample. The substance capable of being specifically bound is generally an immunochemical substance. The combination comprises a novel adapter which eliminates contact with the sample, while providing reproducibility of test results, so that many samples can be tested manually and economically in a relatively short period of time. The novel combination comprises (1) a fiber optic color- imeter comprising a light source, a means for detecting and measuring light, and a probe containing a plurality of optic fibers including a first light conducting means for conducting light from the light source of the colorimeter to a test sample and a second light conducting means for conducting light from the test sample to the means for detecting and measuring light of the colorimeter, and (2) a microplate having one or more wells, each of which is adapted to contain a liquid test sample, for use in a predetermined colorimetric medical diagnostic test, wherein a reflective surface is disposed below the bottom of the well of said microplate, and said well is adapted to accommodate the probe of said fiber optic colorimeter, and wherein said probe includes an attachments means joinable in a close-fitting engage- ment with an upper portion of each well in said microplate with- out engaging said liquid sample. The detection and measurement of an immunochemical substance using the method and apparatus of the invention involves providing for the agglutination of a sus- pension of particles in a sample, or color intensity of solutions, by which, using the combination of the invention to determine certain electromagnetic radiation properties of the sample, the presence and amount of the immunochemical substance can be determined. The method of the invention is especially suitable for rapid manual examination of samples in wells of microplates that are commercially available.
323593
Linnecke Carl B.
Wong Daniel
Akzona Incorporated
Swabey Ogilvy Renault
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