Process for the manufacture of acyl derivatives

C - Chemistry – Metallurgy – 07 – D

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260/104.1

C07D 501/36 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/46 (2006.01)

Patent

CA 1146165

ABSTRACT OF THE DISCLOSURE A process for the manufacture of novel antibiotics of the general formula Image I wherein X represents the group Image or Image (a) (b) as well as of salts of these compounds and hydrates of these compounds and salts, which process comprises reacting a halide of the general formula Image II wherein X has the significance given earlier and Y represents a halogen atom, or a salt thereof with thiourea and, if desired, converting a compound of for mula I obtained into a salt or hydrate or into a hydrate of sald salt.

364648

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