Process for the preparation of new azines and their tautomers

C - Chemistry – Metallurgy – 07 – D

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260/305.3, 260/3

C07D 233/86 (2006.01) C07D 277/54 (2006.01)

Patent

CA 1043338

ABSTRACT of the Disclosure The present invention relates to a process for the preparation of new azines and their tautomers corres- ponding to the general formula I Image (I) wherein one of the symbols R1 and R2 represents allyl, 1-methylallyl, 2-methylallyl or 2-propynyl, and the other likewise one of these groups, or methyl, R3 and R4 each independently represent hydrogen or methyl, and X represents hydrogen or hydroxyl, and wherein in the right half of the formula bonds corresponding to the dotted lines or to the dashed lines are present, and in the left half of the formula, in the case where X denotes hydrogen, bonds corresponding to the dotted lines or, in the case where X represents hydroxyl, corresponding to the dotted lines or to the dot-dash lines are present. These new compounds possess valuable pharmaco- logical properties and are active ingredients for thera- peutic compositions. In particular, they inhibit the growth of tumours, while their toxicity is low in com- parison with their tumour-inhibiting effectiveness.

191994

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