Synthesis of oxindoles from anilines and intermediates therein

Details Synthesis of oxindoles from anilines and intermediates therein Synthesis of oxindoles from anilines and intermediates therein

C - Chemistry, Metallurgy

07

D

260/319, 260/541

C07D 209/34 (2006.01)

Patent

CA 1042447

Abstract of Disclosure Preparing oxindoles and intermediates therefor by reacting an N-haloaniline with .beta.-thio esters or .beta.-thio amides to form an azasulfonium halide, reacting the azasulfonium halide with a base to form an ortho-[thio- ether (hydrocarbonoxycarbonyl) alkyl]aniline, or a [thio- ether (aminocarbonyl) alkyl]aniline, reacting the ortho- substituted aniline with an acid to form a 3-thio-ether- 2-oxindole, and then reducing the 3-thio-ether-2-oxindole with Raney Nickel to form the 2-oxindole.

198271

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