Process for preparing oxaprostaglandins

Details Process for preparing oxaprostaglandins Process for preparing oxaprostaglandins

C - Chemistry, Metallurgy

07

C

260/235.03

C07C 405/00 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1095034

ABSTRACT OF THE DISCLOSURE .omega.-Trisnorprostaglandins of the formula: Image having at the 17-position two hydrogen atoms and one substituent of the formula: (CH2)n-O-(CH2)mCH3 wherein n is an integer of from 0 to 2, m is an integer of from o to 4; with the proviso that the sum of n and m does not exceed 6; and having at the 15-position one hydrogen substituent or alkyl substituent of from 1 to 3 carbon atoms. The novel prosta- glandins of this invention have been found to have activity pro- files comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.

173035

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