Substituted-phenyl substituted-alkyl ethers and the...

Details Substituted-phenyl substituted-alkyl ethers and the... Substituted-phenyl substituted-alkyl ethers and the...

C - Chemistry, Metallurgy

07

D

260/295, 260/309

C07D 277/82 (2006.01) C07D 213/74 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1050985

ABSTRACT OF THE DISCLOSURE The disclosure relates to substituted-phenyl substituted- alkyl ethers of the formula: Image wherein R1 is lower alkyl, cycloalkyl, aryl, ar(lower) alkyl, a heterocyclic group or a group represented by the formula: Image wherein R3 and R4 are each hydrogen or lower alkyl, R5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene: R2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: Image wherein R3, R4, R5 and A are each as defined above: R3, R4, R5 and A are each as defined above; and R6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R1 and R2 may be substituted with halogen, hydroxy or lower alkoxy, and when R1 and R2 are both lower alkyl, R1 and R2 may be linked together; and pharmaceutically acceptable salts thereof. These ethers have hypolipidemic activity. Processes for preparing these compounds are also disclosed.

228557

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