C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/89, 260/336.
C12P 19/00 (2006.01) C07D 205/02 (2006.01)
Patent
CA 1050459
ABSTRACT OF THE DISCLOSURE A new process is provided for preparing a new substance 3-amino-1-(.alpha.-carboxy-4-hydroxybenzyl)-2-azetidinone, its salt or its derivative at the carboxy group the process comprises N- deacylating 3-(.alpha.-substituted or unsubstituted glycinamido)-1- (.alpha.-carboxy-4-hydroxybenzyl)-2-azetidinone, its salt or its deriva- tive at the carboxy group in the presence of a cultured broth of a microorganism or its processed material or an amino-pepti- dase derived from an animal body, which is capable of N-deacyl- ating 3-(.alpha.-substituted or unsubstituted glycinamido)-1-(.alpha.- carboxy-4-hydroxybenzyl)-2-azetidinone, its salt or its deriva- tive at the carboxy group to produce 3-amino-1-(.alpha.-carboxy-4- hydroxybenzyl)-2-azetidinone, its salt or its derivative at the carboxy group; the new substance is useful as an intermediate for preparing antibacteria1 3-acylamino azetidinone derivatives.
251978
Aoki Hatsuo
Imanaka Hiroshi
Kunugita Kiyohiko
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