Cyclic undecapeptide analogs of somatostatin and intermediates

Details Cyclic undecapeptide analogs of somatostatin and intermediates Cyclic undecapeptide analogs of somatostatin and intermediates

C - Chemistry, Metallurgy

07

K

530/7.26

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1066695

ABSTRACT OF THE DISCLOSURE Cyclic undecapeptide analogs of somatostatin without cysteine amino acid residues and intermediates obtained in the synthesis of such compounds are described. The undecapeptide has the formula Image in which Trp represents either D- or L-tryptophyl and all the other amino acids are of the L-configuration and wherein n is a whole number from 1 through 5. These cyclic undecapeptides inhibit the secretion of the hormone somatotropin (growth hor- mone) without materially affecting glucagon levels.

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