1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b...

Details 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b... 1,1'-(1,2-ethynediyl)bis-benzene derivatives as ptp 1-b...

C - Chemistry, Metallurgy

07

D

C07D 333/34 (2006.01) A61K 31/165 (2006.01) A61P 3/10 (2006.01) C07C 65/03 (2006.01) C07C 211/44 (2006.01) C07C 233/65 (2006.01) C07C 311/15 (2006.01)

Patent

CA 2560648

The present invention is related to carboxylic acids of Formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of carboxylic acids of Formula (I) to modulate, notably to inhibit the activity of PTPs.

L'invention concerne des acides carboxyliques de formule (I) et leur utilisation pour le traitement et/ou la prévention de l'obésité et/ou des troubles métaboliques dont la médiation est assurée par la résistance insulinique ou l'hyperglycémie, à savoir le diabète de type I et/ou II, la tolérance au glucose inadéquate, la résistance insulinique, l'hyperlipémie, l'hypertriglycéridémie, l'hypercholestérolémie, le syndrome des ovaires polykystiques, et en particulier l'invention concerne l'utilisation des acides considérés pour la modulation, et notamment l'inhibition de l'activité des PTP.

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