1,1,1 triaryl alkylamines

Details 1,1,1 triaryl alkylamines 1,1,1 triaryl alkylamines

C - Chemistry, Metallurgy

07

D

260/270, 260/278

C07D 223/14 (2006.01) A61K 31/395 (2006.01) A61K 31/445 (2006.01) C07C 57/38 (2006.01) C07C 57/72 (2006.01) C07D 209/52 (2006.01) C07D 209/70 (2006.01) C07D 211/22 (2006.01) C07D 211/52 (2006.01) C07D 211/64 (2006.01) C07D 211/96 (2006.01) C07D 217/04 (2006.01) C07D 221/22 (2006.01) C07D 223/04 (2006.01) C07D 295/00 (2006.01) C07D 333/08 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 1072089

Abstract of the Disclosure The present invention is concerned with 1,1,1-triaryl-alkylamines. These compounds are pre- pared by reacting the appropriate amides with a suitable hydride reducing agent in an organic solvent to give the compounds of the instant invention. Alter- nately, the compounds of the present invention can also be prepared by reacting the appropriate organometallic compounds with an haloalkylamine. The compounds of the instant invention possess potent anti-diarrheal utility as evidenced by their ability to inhibit gastrointestinal motility. These subject compounds also possess a very low degree of analgesia.

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