1,1,1-trifluoro-2-hydroxypropyl compounds

Details 1,1,1-trifluoro-2-hydroxypropyl compounds 1,1,1-trifluoro-2-hydroxypropyl compounds

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/437 (2006.01) C07D 213/30 (2006.01) C07D 213/61 (2006.01) C07D 213/64 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 241/12 (2006.01) C07D 241/42 (2006.01) C07D 333/38 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 471/02 (2006.01)

Patent

CA 2754184

The present invention relates to compounds of formula I wherein R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

La présente invention concerne de composés de formule I dans laquelle Rla à Rle et R2 to R5 sont tels que définis dans la description et les revendications, et leurs sels pharmaceutiquement acceptables. Les composés sont des antagonistes du récepteur des glucocorticoïdes utiles pour le traitement et/ou la prévention de maladies telles que le diabète, la dyslipidémie, l'obésité, l'hypertension, les maladies cardiovasculaires, le déséquilibre surrénalien ou la dépression.

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