1,1-alkanediol dicarboxylate linked antibacterial agents

Details 1,1-alkanediol dicarboxylate linked antibacterial agents 1,1-alkanediol dicarboxylate linked antibacterial agents

C - Chemistry, Metallurgy

07

D

260/110

C07D 499/32 (2006.01) C07D 499/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1213582

1,1-ALKANEDIOL DICARBOXYLATE LINKED ANTIBACTERIAL AGENTS Abstract Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula Image ---(I) . where A is the residue of certain dicarboxyic acids, R3 is H or (C1-C3)alkyl, n is zero or 1 such that when n is zero R is P or B and R1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R1 is P and the other is B, and P is Image where R2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a process for their production and intermediates therefor.

418192

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