(1)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,12-....

Details (1)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,12-.... (1)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,12-....

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 455/00 (2006.01) A61K 31/44 (2006.01) C07D 471/14 (2006.01)

Patent

CA 1299574

23305-1063 ABSTRACT The invention relates to the new (-)-1.beta.-ethyl-1.alpha.- hydroxymethyl-1,2,3,4,6,7,12,12b.alpha.-octahydroindolo[2,3-a]quinoli- zine of the formula (I) Image (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydro- lysis and/or salt formation. The compound of formula (I) shows a remarkable peri- pheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.

507011

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