C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/58 (2006.01) A61K 31/19 (2006.01) A61K 31/395 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 233/60 (2006.01) C07D 217/06 (2006.01)
Patent
CA 2730208
The present invention relates to compounds defined by formula (I) wherein the group R is defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 .beta.-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases.
La présente invention concerne des composés définis par la formule (I) dans laquelle le groupe R est tel que défini dans la revendication 1, et possédant une activité pharmacologique de valeur. Les composés sont en particulier des inhibiteurs de la 11 ß-hydroxystéroïde déshydrogénase (HSD) de type 1 et sont donc appropriés pour le traitement et la prévention de maladies qui peuvent être influencées par linhibition de cette enzyme, comme les maladies métaboliques.
Eckhardt Matthias
Hamilton Bradford S.
Himmelsbach Frank
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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