1,1-dioxo-2h-1, 2-benzothiazine-3-carboxamide derivatives,...

Details 1,1-dioxo-2h-1, 2-benzothiazine-3-carboxamide derivatives,... 1,1-dioxo-2h-1, 2-benzothiazine-3-carboxamide derivatives,...

C - Chemistry, Metallurgy

07

D

C07D 279/02 (2006.01) A61K 31/54 (2006.01) C07D 213/00 (2006.01) C07D 279/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2432807

The invention concerns a compound of formula (I) wherein: (a) represents a single or double bond; R´1? represents a hydrogen atom or a hydroxy, alkoxy, acyloxy, alkylsulphonyloxy, arylsulphonyloxy or arylalkoxy group; R´2? represents a hydrogen atom or an alkyl group; R´3? and R´4?, identical or different, represent each a hydrogen, a halogen atom or an alkyl, hydroxy or alkoxy group; Ak represents an alkylene chain; R´5?, R´6? and R´7?, identical or different, represent each an alkyl group, or R´5?, R´6? and R´7? together with the nitrogen which bears them, form a saturated or unsaturated nitrogenous heterocycle; X represents a halogen atom; and its optical isomers when they exist.

Formule (I) dans laquelle: (a) repr~sente une liaison simple ou double, R~1 repr~sente un atome d'hydrog~ne ou un groupement hydroxy, alkoxy, acyloxy, alkylsulfonyloxy, arylsulfonyloxy ou arylalkoxy, R~2 repr~sent un atome d'hydrog~ne ou un groupement alkyle, R~3 et R~4, identiques ou diff~rents, repr~sentent chacun un atome d'hydrog~ne, d'halog~ne ou un groupement alkyle, hydroxy ou alkoxy, Ak repr~sente une cha~ne alkyl~ne, R~5, R~6 et R~7, identiques ou diff~rents, repr~sentent chacun un groupement alkyle, ou bien R~5, R~6 et R~7, pris ensemble avec l'atome d'azote qui les porte, forment un h~t~rocycle azot~ satur~ ou insatur~, X repr~sente un atome d'halog~ne, ainsi que ses isom~res optiques lorsqu'ils existent.

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