1,1-disubstituted cyclic inhibitors of matrix...

Details 1,1-disubstituted cyclic inhibitors of matrix... 1,1-disubstituted cyclic inhibitors of matrix...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) C07D 215/14 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2434205

The present application describes novel 1,1-disubstituted cyclic derivatives of formula (I), or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-8 membered non-aromatic ring consisting of: carbon atoms, 0-1 carbonyl groups, 0-1 double bonds, and from 0-2 ring heteroatoms selected from O, N, NR2, S, S(O), and S(O)2 and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF-.alpha. inhibitors.

La présente invention concerne de nouveaux dérivés cycliques 1,1-disubstitués représentés par la formule (I) ou leurs sels pharmaceutiquement acceptables. Dans ladite formule (I), le cycle B est un cycle non aromatique comprenant entre 3 et 8 éléments dont des atomes de carbone, 0 à 1 groupes carbonyle, 0 à 1 doubles liaisons et entre 0 et 2 hétéroatomes cycliques sélectionnés dans le groupe comprenant O, N, NR?2¿, S, S(O), et S(O)¿2? et les autres variables sont définies dans la partie descriptive de la présente demande. Ces dérivés sont utiles comme inhibiteurs de la métalloprotéase et de TNF-.alpha..

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