(1, 10b-dihydro-2-(aminoalkyl- phenyl)-5h-pyraz0l0 [1,5-c]...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 498/04 (2006.01) A61K 31/5365 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2604686

The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti- retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.

La présente invention porte sur des dérivés de méthanone 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phényle utiles comme inhibiteurs de la réplication virale du virus du VIH, ainsi que sur leurs procédés de préparation et leurs compositions pharmaceutiques, sur leur utilisation comme médicaments et sur des kits de diagnostic les comprenant. La présente invention porte également sur des combinaisons des présents inhibiteurs du VIH avec d'autres agents anti-rétroviraux. L'invention porte également sur leur utilisation dans des essais comme composés de référence ou comme réactifs. Les composés de cette invention sont utiles dans la prévention ou le traitement d'une infection par le VIH et dans le traitement du sida.

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