(1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5-...

Details (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5-... (1,10b-dihydro-2-(aminocarbonyl-phenyl)-5h-pyrazolo[1,5-...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/538 (2006.01) C07D 231/00 (2006.01) C07D 265/00 (2006.01)

Patent

CA 2563959

The present invention relates to 5H-pyrazolo[1,5-c] [1,3]benzoxazin-5- yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.

L'invention concerne des dérivés de 5<I>H</I>-pyrazolo[1,5-c] [1,3]benzoxazin-5-yl)phénylméthanone utilisés en tant qu'inhibiteurs de la réplication virale du VIH, des procédés de préparation de ceux-ci et des compositions pharmaceutiques, leur utilisation en tant que médicaments, et des kits diagnostiques les comprenant. L'invention concerne également des combinaisons desdits inhibiteurs du VIH avec d'autres agents antirétroviraux. L'invention concerne en outre leur utilisation dans des analyses en tant que composés de référence ou en tant que réactifs. Les composés de l'invention sont également utiles pour la prévention ou le traitement d'une infection par le VIH et pour le traitement du SIDA.

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