C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/279
C07D 487/04 (2006.01) A61K 31/395 (2006.01)
Patent
CA 1307788
HOE 86/S 015K ABSTRACT OF THE DISCLOSURE There are described compounds of the formula Image where (a) X is O or S; (b) R is H, loweralkyl, Image or -?-R4; where Y is O or S; R2 is loweralkyl, cycloalkyl, bicycloalkyl, cycloalkenyl, aryl, arylloweralkyl, heteroaryl or heteroarylloweralkyl, R3 is H or lower alkyl or the group -NR2R3 taken as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl, 4-methyl-1- piperazinyl or 2-(2,6-dichlorophenylimino)-1- imidazolidinyl) and R4 is hydrogen, loweralkyl, arylloweralkyl, diarylloweralkyl, aryl or heteroaryl, (c) m is 1 or 2; (d) each Z is independently H, loweralkyl, halogen, nitro, -NH2, loweralkylcarbonylamino, arylcarbonylamino, loweralkoxycarbonylamino or loweralkylamino, and - 2 - (e) R1 is H, loweralkyl, arylloweralkyl, heteroarylloweralkyl, cycloalkylmethyl or loweralkenylmethyl, with the proviso that when X is 0, m is 1, Z is H and R1 is methyl, R is not -CONHCH3, -CONHC6H5, hydrogen, methyl or ethyl, and that when X is 0, m is 1 and Z and R1 are both hydrogen, R is not hydrogen or methyl, and pharmaceutically acceptable acid addition salts thereof which are useful as memory-enhancing and analgesic agents.
542153
Chiang Yulin
Glamkowski Edward J.
Hamer Russell Richard Lee
Helsley Grover Cleveland
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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