1,2,3,4-tetrahydro-1,9-acridinediamines, a process for their...

Details 1,2,3,4-tetrahydro-1,9-acridinediamines, a process for their... 1,2,3,4-tetrahydro-1,9-acridinediamines, a process for their...

C - Chemistry, Metallurgy

07

D

167/211, 260/277

C07D 219/10 (2006.01) C07D 221/16 (2006.01) C07D 401/04 (2006.01) C07D 401/08 (2006.01) C07D 413/08 (2006.01)

Patent

CA 2002531

- 1 - ABSTRACT HOE 88/5 031 1,2,3,4- Tetrahydro -1,9- acridinediamines, a process for their preparation and their use as medicaments There are disclosed compounds having the formula Image (I) where n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro or trifluoromethyl; R1 and R2 are each independently hydrogen, loweralkyl or arylloweralkyl, but both may not be arylloweralkyl simultaneously; R3 and R4 are each independently hydrogen, loweralkyl, arylloweralkyl, formyl or loweralkylcarbonyl, or alternatively the group -NR3R4 taken as a whole constitutes -2- Image , Image , Image , Image Image , or Image ; stereo isomers thereof and pharmaceutically acceptable acid addition salts thereof and a process for their preparation. The compounds are useful for the treatment of various memory dysfunctions characterized by decreased cholingeric function, such as Alzheimer's disease, and can, therefore, be used as medicaments.

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