C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/255
C07D 239/22 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01)
Patent
CA 1337655
Cardiovascular activity is exhibited by compounds having the formula Image , and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R1 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, Image , Image or halo substituted alkyl, or R and R1 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, Image , or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, Image , Image , or halo substituted alkyl; R4 is aryl or heterocyclo; R5 and R6 are each independently hydrogen, alkyl, -(CH2)q-aryl or -(CH2)q-cycloalkyl; Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, Image , Image , carboxyl, alkoxycarbonyl, Image , Image , Image or Image Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, Image , carboxyl, alkoxycarbonyl, Image , Image or Image ; Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, Image , Image , amino, or substituted amino; q is 0, 1, 2 or 3; m is 0 or an integer of 1 to 6; n is 0 or an integer of 1 to 5; and p is an integer of 1 to 5.
532125
Atwal Karnail Singh
Rovnyak George Charles
E.r. Squibb & Sons Inc.
Osler Hoskin & Harcourt Llp
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