1,2,3,4-tetrahydro-benzofuro[3,2-c]pyridine derivatives

Details 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyridine derivatives 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/435 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2264598

The present invention concerns the compounds of formula (I), the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein each R1 is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; Alk is C1-6alkanediyl; n is l or 2; D is an optionally substituted mono-, bi- or tricyclic nitrogen containing heterocycle having central .alpha.2-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine.

L'invention porte sur des composés de formule (I), leurs oxydes N-, leurs sels d'addition pharmacocompatibles et leurs formes stéréochimiquement isomères dans laquelle: chaque R<1> est indépendamment H, halogène, C1-6 alkyle, nitro, hydroxy ou C1-4 alkyloxy; Alk est C1-6 alkanédiyle; n est 1 ou 2; D est un hétérocycle mono, bi ou tricyclique facultativement substitué contenant un azote, et qui présentent une activité d'antagoniste de l'adrénorécepteur central alpha 2. L'invention porte également sur leur préparation, des compositions les comprenant et leur utilisation comme médicament.

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