1,2,3,4-tetrahydroisoquinoline antiarrhythmic agents

Details 1,2,3,4-tetrahydroisoquinoline antiarrhythmic agents 1,2,3,4-tetrahydroisoquinoline antiarrhythmic agents

C - Chemistry, Metallurgy

07

D

167/226, 260/283

C07D 217/16 (2006.01) A61K 31/47 (2006.01) C07D 217/06 (2006.01) C07D 401/04 (2006.01)

Patent

CA 1332415

ABSTRACT 1,2,3,4-Tetrahydroisoquinoline Antiarrhythmic Agents Isoquinoline antiarrhythmic agents of the formula:- Image --- (I) and their pharmaceutically acceptable salts, wherein one of R1 and R2 is methoxy and the other is a group of the formula -OH, -O.CO(C1-C4 alkyl), -O.COPh or -O.COCH2Ph where Ph is a phenyl group optionally substituted by one or two substituents each independently selected from F, Cl, Br, I, CF3, C1-C4 alkyl and C1-C4 alkoxy.

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