1,2,3,4-tetrahydroisoquinoline derivatives

Details 1,2,3,4-tetrahydroisoquinoline derivatives 1,2,3,4-tetrahydroisoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 3/04 (2006.01) A61P 25/20 (2006.01) C07D 217/12 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2402431

The invention relates to novel 1,2 3,4-tetrahydroisochi- noline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

L'invention concerne des dérivés de 1,2,3,4-tétrahydroisoquinoline de formule (I) ainsi que leurs utilisations comme principes actifs dans la préparation de compositions pharmaceutiques. Elle concerne aussi des aspects s'y rapportant comprenant des procédés de préparation de ces composés, des compositions pharmaceutiques qui contiennent un ou plusieurs de ces composés, et spécialement leur utilisation comme antagonistes du récepteur de l'orexine.

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