1,2,3,4-tetrahydroisoquinoline derivatives, preparations...

Details 1,2,3,4-tetrahydroisoquinoline derivatives, preparations... 1,2,3,4-tetrahydroisoquinoline derivatives, preparations...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4725 (2006.01) A61K 31/4741 (2006.01) A61P 25/04 (2006.01) A61P 25/22 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2550643

Compounds of general formula (I) wherein D, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Selon l'invention, on prépare des composés de formule générale (I), dans laquelle D, E, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et R?7¿ sont tels que définis dans la description, ainsi que des sels et des énantiomères de ces composés et des compositions pharmaceutiques renfermant lesdits composés, lesquels peuvent être utilisés à des fins thérapeutiques, notamment dans la gestion de la douleur.

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