1,2,3,4-tetrahydroisoquinolines and the preparation thereof

Details 1,2,3,4-tetrahydroisoquinolines and the preparation thereof 1,2,3,4-tetrahydroisoquinolines and the preparation thereof

C - Chemistry, Metallurgy

07

D

260/289.3, 260/2

C07D 217/14 (2006.01)

Patent

CA 1051902

ABSTRACT OF THE DISCLOSURE New 1,2,3,4-tetrahydroisoquinolines and processes for their preparation are provided; the new compounds may be re- presented by the formula: (I) Image wherein R1 and R2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which the aryl and the aryl moiety of the ar(lower)alkyl may have substituent(s) selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo- (lower)alkyl, acylamino, ar(lower)alkylamino and aryl; the new 1,2,3,4-tetrahydroisoquinolines and their pharmaceutically acceptable salts have relaxing activity on smooth muscles, especially on vascular- and visceral-smooth muscles.

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