C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/47 (2006.01) A61P 9/00 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 407/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2441790
The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists especially urotensin II antagonists.
La présente invention concerne des dérivés de 1,2,3,4-tétrahydro-isoquinoline de formule (I) et des composés associés, ainsi que leur utilisation en tant que substances actives pour la préparation de compositions pharmaceutiques. D'autres aspects de l'invention comprennent des procédés permettant la préparation desdits composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés et en particulier leur utilisation en tant qu'antagonistes neurohormonaux notamment en tant qu'antagonistes de l'urotensine II.
Aissaoui Hamed
Binkert Christoph
Clozel Martine
Mathys Boris
Mueller Claus
Actelion Pharmaceuticals Ltd.
Gowling Lafleur Henderson Llp
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