1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and use

Details 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and use 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and use

C - Chemistry, Metallurgy

07

D

C07D 215/38 (2006.01) A61K 31/395 (2006.01) A61K 31/47 (2006.01) A61K 31/695 (2006.01) A61K 51/04 (2006.01) C07D 215/42 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2163867

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotropic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convultions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a substituted or unsubstituted 1,2,3,4-tetrahydroquinoline-2,3,4trione-3 or 4-oxime or pharmaceutically acceptable salts thereof which have high binding to the glycine receptor.

Procédés de traitement ou de prévention de la déficience neuronale associée aux attaques, à l'ischémie, au trauma du système nerveux central, à l'hypoglycémie et la chirurgie, et procédé de traitement des maladies neurodégénératives y compris la maladie d'Alzheimer, la sclérose latérale amyotrophique, la maladie de Huntington et le syndrome de Down, de traitement ou de prévention des effets secondaires de l'hyperactivité des acides aminés excitateurs, et de traitement de l'anxiété, de la douleur chronique, des convulsions et d'induction de l'anesthésie, consistant à administrer à un animal ayant besoin d'un tel traitement 1,2,3,4-tétrahydroquinoline-2,3,4-trione-3 ou 4-oxime subsituté ou non substitué ou des sels pharmaceutiquement acceptables de celui-ci, ces composés ayant un fort pouvoir de fixation sur le récepteur de glycine.

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