1,2,3,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-(8a.beta.)-6-...

Details 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-(8a.beta.)-6-... 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-(8a.beta.)-6-...

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/47 (2006.01) C07D 217/02 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2148002

- 45 - ABSTRACT OF THE DISCLOSURE Image (I) 1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl- (8a.beta.)-isoquinolineamines of formula (I), wherein groups R1-R3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.

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