1,2,3,9-tetrahydro-3-¬(imidazol-1-yl) methyl|...

Details 1,2,3,9-tetrahydro-3-¬(imidazol-1-yl) methyl|... 1,2,3,9-tetrahydro-3-¬(imidazol-1-yl) methyl|...

C - Chemistry, Metallurgy

07

D

167/238, 260/305

C07D 403/06 (2006.01) A61K 31/415 (2006.01) C07D 209/88 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1252793

A B S T R A C T Heterocyclic Compounds The invention relates to compounds of formula (I). Image (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl group, and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates, e.g. hydrates, thereof. The compounds are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.

472888

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