1, 2, 3- triazole amide derivatives as cytokine inhibitors

Details 1, 2, 3- triazole amide derivatives as cytokine inhibitors 1, 2, 3- triazole amide derivatives as cytokine inhibitors

C - Chemistry, Metallurgy

07

D

C07D 249/06 (2006.01) A61K 31/4192 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2507184

Disclosed are compounds of formula (I). Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

La présente invention concerne des composés représentés par la formule générale (I). Dans cette formule, les Ar¿1?, X, R¿3?, R¿4?, R¿5? et R¿6? sont tels que définis dans la présente demande. En l'occurrence, les composés de l'invention bloquent la production de cytokines impliquées dans les processus inflammatoires. Cela fait qu'ils conviennent pour le traitement de maladies et d'états pathologiques mettant en jeu des phénomènes inflammatoires tels que la maladie inflammatoire chronique. L'invention concerne également, d'une part des procédés permettant l'élaboration de ces composés, et d'autre part des compositions pharmaceutiques comprenant ces composés.

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