C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 249/06 (2006.01) A61K 31/4192 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2614919
The invention relates to compounds of structural formula (I): formula (I) or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein R a, R b, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
La présente invention concerne des composés représentés par la formule (I) ou un sel, un solvate, un clathrate et un précurseur de médicament pharmaceutiquement acceptable de ces derniers. Dans la formule, R<SUB>a</SUB>, R<SUB>b</SUB> et R<SUB>2</SUB> sont tels que spécifiés dans le descriptif. Ces composés inhibent la polymérisation des tubulines et/ou ciblent le système vasculaire et sont par conséquent utiles pour traiter les maladies prolifératives, telles que le cancer.
Borella Christopher
Chen Shoujun
Demko Zachary
Sun Lijun
Gowling Lafleur Henderson Llp
Synta Pharmaceuticals Corp.
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