1,2,4-benzothiadiazine 1,1-dioxide derivatives

Details 1,2,4-benzothiadiazine 1,1-dioxide derivatives 1,2,4-benzothiadiazine 1,1-dioxide derivatives

C - Chemistry, Metallurgy

07

D

260/243.2

C07D 417/04 (2006.01) C07D 285/24 (2006.01) C07D 295/00 (2006.01)

Patent

CA 1056827

ABSTRACT OF THE DISCLOSURE A compound of the formula Image wherein R1 represents a hydrogen atom or a lower alkyl group, and R2 represents a hydrogen or halogen atom or a trifluoromethyl group, and its pharmaceutically acceptable salt. The compound is prepared by reacting the corresponding 1,2,4-benzothiadiazine 1,1- dioxide with a piperazine compound or alkylating 1,2,4-benzothia- diazine 1,1-dioxide whose corresponding 3-position is substituted by a piperazinyl group. The above compound has superior anti- hypertensive activity separated from diuretic, antidiuretic and hyperglycemic actiivties, and is free from side-effects. - 1 -

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