1,2,4-oxadiazole benzoic acid compounds

Details 1,2,4-oxadiazole benzoic acid compounds 1,2,4-oxadiazole benzoic acid compounds

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01)

Patent

CA 2521992

Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

L'invention concerne des composés d'acide benzoïque 1,2,4-oxadiazole, des procédés d'utilisation et des compositions pharmaceutiques renfermant un dérivé de l'acide benzoïque 1,2,4-oxadiazole. Parmi les procédés d'utilisation, on peut citer des méthodes de traitement ou de prévention d'une maladie améliorée par la modulation de la fin précoce de la translation ou de la dégradation des ARNm induite par non-sens ou d'amélioration d'un ou plusieurs symptômes associés à celle-ci.

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