1, 2, 4 -oxadiazole derivatives and their therapeutic use

Details 1, 2, 4 -oxadiazole derivatives and their therapeutic use 1, 2, 4 -oxadiazole derivatives and their therapeutic use

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2748397

New derivatives of general formula (I), or pharmaceutically acceptable salts or N- oxides thereof wherein,either (i) A is selected from the group consisting of -N-, -O- and -S-; B and C are independently selected from the group consisting of -N- and -O-, with the proviso that two of A, B and C are nitrogen atoms, or (ii) two of A, B and C are -N- and one of A, B and C is -NH-; Gl is se-lected from the group consisting of -CH2-, -NH- and -O-; G2 is selected from the group consisting of -NR4- and -O-; R1 represents: > a 8 to 10 membered bicyclic N-containing heteroaryl group optionally substituted with a C1-4 car-boxyalkyl group or a C1-4 aminoalkyl group, > a pyridyl group optionally substituted with one or more substituents selected from hydroxy groups, C1-4 alkyl groups, C1-4 car-boxyalkyl groups, C1-4 haloalkyl groups, C1-4 alkoxy groups, amino groups, C1-4 aminoalkyl groups and C1-4 aminoalkoxy groups, > a pyridone group substituted with one or more C1-4 alkyl groups; C1-4 haloalkyl groups or C1-4 aminoalkyl groups, or > a group of formula:

La présente invention concerne de nouveaux dérivés de formule générale (I), les sels pharmaceutiquement acceptables et les N-oxydes de ceux-ci.

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