1, 2, 4-oxadiazole derivatives as hppar alpha agonists

Details 1, 2, 4-oxadiazole derivatives as hppar alpha agonists 1, 2, 4-oxadiazole derivatives as hppar alpha agonists

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2430847

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein: X1 is O or S; X2 is O or S; n is 1-3; One of Y and Z is N, and the other is O; R1 and R2 are independently halogen, H, CH3, OCH3 or C1-3 alkyl; Each R3 independently is halogen, CF3, C1-6 straight or branched alkyl; R4 and R5 are independently H or C1-3 alkyl. y is 0, 1, 2, 3, 4 or 5.

L'invention concerne un composé de la formule (I), ainsi que des sels, solvates et esters hydrolysables, pharmaceutiquement acceptables de ce composé. Dans la formule (I), X?1¿ représente O ou S ; X?2¿ représente O ou S ; n est compris entre 1 et 3 ; un des deux éléments Y et Z représente N, et l'autre représente O ; R?1¿ et R?2¿ représentent indépendamment halogène, H, CF¿3?, OCH¿3? ou alkyle C¿1-3? ; chaque R?3¿ représente indépendamment halogène, CF¿3?, alkyle C¿1-6? linéaire ou ramifié ; R?4¿ et R?5¿ représentent indépendamment H ou alkyle C¿1-3?. Y est 0, 1, 2, 3, 4 ou 5.

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