1,2,4-oxadiazole derivatives, their preparation and...

Details 1,2,4-oxadiazole derivatives, their preparation and... 1,2,4-oxadiazole derivatives, their preparation and...

C - Chemistry, Metallurgy

07

D

260/266.4, 260/3

C07D 403/00 (2006.01) C07D 271/00 (2006.01) C07D 271/07 (2006.01)

Patent

CA 1130806

A B S T R A C T 1,2,4-Oxadiazole derivatives of the formula: Image (I) represents a hydrogen or halogen atom or an alkyl radical, or two radical selected from R1, R2, R3, R4, and R5 bonded to adjacent carbon atoms of the benzene ring represent a group of formula -CH=CH-CH=CH-, thus converting said benzene ring into a naphthalene ring provided that at least two radicals selected from R1, R2, R3, R4, and R5 have an above-defined meaning other than hydrogen atoms; and R represents a radical selected from (i) and (ii) Image in which each of R'1 and R'2 independently represents an alkyl radical, a hydroxyalkyl radical or an N,N-dialkyl- aminoalkyl radical, or N, R'1 and R'2 together form a radical Image each of the above-specified alkyl radicals and individual alkyl portions of radical having from 1 to 4 carbon atoms; are pharmaceutically useful as anti-hypertensive agents.

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