C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/4245 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2731873
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
La présente invention porte sur des composés de formule (I) : et sur des sels, stéréo-isomères ou tautomères pharmaceutiquement acceptables de ceux-ci qui sont des inhibiteurs de la voie Sonic Hedgehog, en particulier des antagonistes de Smo. Ainsi, les composés de cette invention sont utiles pour le traitement de maladies associées à une activation anormale de la voie Hedgehog, en particulier le cancer, par exemple le carcinome des cellules basales, le médulloblastome, les cancers de la prostate, pancréatique, du sein, du côlon, des os et du poumon à petites cellules, et les cancers de tractus gastro-intestinal supérieur.
Bufi Laura Llauger
Dessole Gabriella
Jones Philip
Muraglia Ester
Ontoria Ontoria Jesus Maria
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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