1,2,4-oxadiazolonylacetyl penicillins and cephalosporins

C - Chemistry – Metallurgy – 07 – D

Patent

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260/106.1, 260/1

C07D 499/70 (2006.01) C07D 271/07 (2006.01) C07D 499/00 (2006.01) C07D 501/24 (2006.01)

Patent

CA 1068679

Abstract 1,2,4-Oxadiazolonylacetyl penicillins and cephalo- sporins of the general formula Image wherein A is either Image or Image R1 is hydrogen, lower alkyl or phenyl-lower alkyl; R2 is hydrogen lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or pyridyl; R3 is hydrogen, lower alkyl, phenyl- lower alkyl, a salt forming ion, trimethylsilyl, benzhydryl, or -CH2-O-?-R4; R4 is lower alkyl, phenyl or phenyl-lower alkyl; and x is hydrogen, lower alkoxy, lower alkanoyloxy, lower alkylmercapto, the radical of a nitrogen base, or certain heterocyclic thio moieties; are disclosed. They are useful as antibacterial agents.

228973

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