C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/235, 260/303
C07D 413/12 (2006.01) A61K 31/42 (2006.01) C07D 261/08 (2006.01) C07D 271/06 (2006.01)
Patent
CA 2022691
Compounds of the formulae (see Formula I and II) wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or tri- fluoromethyl; and R8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R8 is hydrogen R' is hydroxy-lower-alkyl, are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
Bailey Thomas Robert
Diana Guy Dominic
Sanofi-Synthelabo
Sterling Drug Inc.
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