1,2,4-substituted 1,2,3,4-tetrahydro-and 1,2...

Details 1,2,4-substituted 1,2,3,4-tetrahydro-and 1,2... 1,2,4-substituted 1,2,3,4-tetrahydro-and 1,2...

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) C07D 215/12 (2006.01) C07D 215/50 (2006.01) C07D 241/42 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2520405

Quinoline and quinoxaline compounds of formula I and III wherein the subtituent are as defined in claims 1 and 15, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

Composés de quinoléine et de quinoxaline selon les formules I et III, dans lesquelles les substituants sont tels que définis dans les revendications 1 et 15, compositions pharmaceutiques contenant de tels composés et utilisation de ces composés pour augmenter certains taux de lipides plasmatiques, y compris le cholestérol à lipoprotéines de haute densité (HDL) et abaisser certains autres taux de lipides plasmatiques, tels que le cholestérol à lipoprotéines de basse densité (LDL) et les triglycérides, et ainsi traiter des maladies exacerbées par de faibles taux de cholestérol HDL et/ou des taux élevés de cholestérol LDL et de triglycérides, telles que l'athérosclérose et les maladies cardio-vasculaires chez certains mammifères, y compris l'homme.

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