1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone...

Details 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone... 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone...

C - Chemistry, Metallurgy

07

D

C07D 253/06 (2006.01) A61K 31/53 (2006.01) C07D 253/075 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2455235

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Cette invention a trait à des antagonistes du récepteur de la GnRH, se révélant des plus utiles pour traiter divers états pathologiques en relation avec les hormones sexuelles, tant chez l'homme que chez la femme. Les composés selon l'invention correspondent à la structure suivante : Dans cette formule, R¿1?, R¿2?, R¿3a?, R¿3b?, R¿4?, R¿5? et n sont tels que définis dans le descriptif, notamment des stéréo-isomères, des promédicaments et leurs sels acceptables du point de vue pharmaceutique. Il est également question de compositions renfermant un composé selon l'invention, associé à un excipient acceptable du point de vue pharmaceutique. L'invention concerne, en outre, des méthodes d'utilisation de ces composés à des fins antagonistes à l'encontre de l'hormone de libération des gonadotrophines et ce, chez des patients nécessitant un tel traitement.

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