1,2,4-triazolidine-3,5-dione derivatives

Details 1,2,4-triazolidine-3,5-dione derivatives 1,2,4-triazolidine-3,5-dione derivatives

C - Chemistry, Metallurgy

07

D

260/313.3

C07D 249/08 (2006.01)

Patent

CA 1101870

ABSTRACT OF THE DISCLOSURE A compound of formula (I): Image (I) wherein; n is 1 to 5 Y is-CH2 -CH2 or -CH=CH-; R1 is hydrogen or C02R1 represents an ester group in which the R1 moiety contains from 1-12 carbon atoms R2 is hydrogen, C1-4 alkyl, or phenyl, R3 is hydroxy or protected hydroxy, R4 is hydrogen, C1-9 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-6 alkyl, phenyl, phenyl -C1-6 alkyl, naphthyl, naphthyl C1-6 alkyl, any of which phenyl moieties or naph- thyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkyl, hydroxy, C1-6 alkoxy, phenyl C1-6 alkoxy or nitro groups, R5 is hydrogen, C1-6 alkyl, C5-8 cycloalkyl, phenyl, phenyl- C1-6 alkyl or phenyl C3-6 cycloalkyl, any of which phenyl moieties may be substituted by one or more halogen, tri- fluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro groups or R2 and R4 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group, and salts thereof; has useful pharmacological activity.

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