[1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use...

Details [1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use... [1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 7/04 (2006.01) A61P 7/06 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 21/04 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2526211

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow. (see formula 1)

L'invention concerne un nouveau dérivé de [1,2,4]triazolo[1,5-a]pyrimidine ainsi qu'un promédicament ou un sel pharmaceutiquement acceptable dudit dérivé. Le dérivé selon l'invention, qui est représenté par la formule générale (1) et qui présente une activité inhibant la présentation d'antigènes, est utile en tant qu'agent prophylactique et/ou agent thérapeutique conçu pour le rejet immunologique et/ou le rejet de greffe dans la transplantation d'organes ou de moelle osseuse, dans le cas de maladies auto-immunes, de maladies allergiques et/ou de maladies inflammatoires et également utile en tant que médicament anticancéreux ou qu'inducteur de tolérance immunologique pour permettre la transplantation d'organes ou de moelle osseuse.

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