1,2,4-triazolo¬1,5-c|pyrimidine heterocyclic analogues...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/14 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2227991

The compounds of general formula (I), wherein A is a pyrazole, imidazole or triazole ring, R is formula (II), wherein R1 and R2, which are the same or different, are H, OH, halogen, C1-4 alkoxy, C1-4 alkyl, nitro, amino, cyano, C1-4 haloalkyl, C1-4 haloalkoxy, carboxy, carboxamido groups; moreover the OH group, together with one of R1 or R2, or R1 and R2, can form the methylenedioxy group -O-CH2-O-; n is an integer from 0 to 4, are useful as therapeutical agents.

L'invention concerne les composés représentés par la formule (I) qui sont utiles en tant qu'agents thérapeutiques. Dans la formule (I) A est un noyau pirazole, imidazole ou triazole, R est représenté par la formule (II) dans laquelle R¿1? et R¿2?, qui sont identiques ou différents, sont H, ou un groupe OH, halogène, C¿1?-C¿4? alkoxy, C¿1?-C¿4? alkyle, nitro, amino, cyano, C¿1?-C¿4? haloalkyle, C¿1?-C¿4? haloalkoxy, carboxy, carboxamido; le groupe OH peut en outre former, en association avec R¿1? ou R¿2?, ou bien avec R¿1? et R¿2?, le groupe méthylènedioxy -O-CH¿2?-O-; n est un entier compris entre 0 et 4.

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