C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/28 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2760741
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ("mGluR2"), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
La présente invention concerne de nouveaux dérivés de triazolo[4,3-a]pyridine de formule (I) dans laquelle tous les radicaux sont tels que définis dans les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs du récepteur métabotropique du glutamate de sous-type 2 ("mGluR2"), qui sont utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate et à des maladies dans lesquelles intervient le sous-type mGluR2 de récepteurs métabotropiques. L'invention concerne également des compositions pharmaceutiques qui comportent de tels composés, des procédés de préparation de tels composés et compositions, et l'utilisation de tels composés pour la prévention ou le traitement de troubles et de maladies neurologiques et psychiatriques dans lesquels mGluR2 intervient.
Cid-Nunez Jose Maria
Macdonald Gregor James
Oehlrlch Daniel
Trabanco-Suarez Andres Avelino
Tresadern Gary John
Addex Pharma S.a.
Janssen Pharmaceutica Inc.
Smart & Biggar
LandOfFree
1,2,4-triazolo [4,3-a] pyridine derivatives and their use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,2,4-triazolo [4,3-a] pyridine derivatives and their use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2,4-triazolo [4,3-a] pyridine derivatives and their use... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1750503