C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 519/00 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2760259
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ("mGluR2"), which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.
La présente invention a pour objet de nouveaux dérivés de la triazolo [4,3-a] pyridine de Formule (I), tous les radicaux étant tels que définis dans les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs du récepteur métabotropique du glutamate du sous-type 2 (« mGluR2 »), qui sont utiles pour le traitement ou la prévention des troubles neurologiques et psychiatriques associés au dysfonctionnement du glutamate et aux maladies dans lesquelles le sous-type mGluR2 des récepteurs métabotropiques est impliqué. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés pour préparer ces composés et compositions, et l'utilisation de ces composés pour la prévention ou le traitement des troubles et maladies neurologiques et psychiatriques dans lesquels le mGluR2 est impliqué.
Cid-Nunez Jose Maria
de Lucas Olivares Ana Isabel
Macdonald Gregor James
Trabanco-Suarez Andres Avelino
Addex Pharma S.a.
Janssen Pharmaceuticals Inc.
Smart & Biggar
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